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Phenotypes Associated with This Genotype
Genotype
MGI:3836962
Allelic
Composition
Ptch1tm1Mps/Ptch1+
Tg(Atoh1-GFP)1Jejo/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (23 available)
Tg(Atoh1-GFP)1Jejo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 80-95% of tumor cells express GFP
• GFP+ tumor cells but not GFP- are able to propagate tumors into immunocompromised hosts

neoplasm
• 80-95% of tumor cells express GFP
• GFP+ tumor cells but not GFP- are able to propagate tumors into immunocompromised hosts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:144811


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory