About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3836921
Allelic
Composition
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic
Background
B6.129P2-Tcrbtm1Mom Igh-Jtm2(3H9-VDJ*)Mwg Tcrdtm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm2(3H9-VDJ*)Mwg mutation (3 available); any Igh-J mutation (14 available)
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (91 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
• spleen has 1.9- to 2.9- fold fewer spleen cells than controls
• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice from 1 to 3 months of age
• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present with levels of IgG3 extremly high compared to controls
• at 3 months of age, levels are higher than those found in 56R mice that have peripheral T cells

hematopoietic system
• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
• spleen has 1.9- to 2.9- fold fewer spleen cells than controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/22/2022
MGI 6.21
The Jackson Laboratory