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Phenotypes Associated with This Genotype
Genotype
MGI:3836920
Allelic
Composition
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
Genetic
Background
B6.129P2-Igh-Jtm2(3H9-VDJ*)Mwg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm2(3H9-VDJ*)Mwg mutation (3 available); any Igh-J mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
• mice have 2.4-fold fewer B cells than controls
• spleen has 1.6-fold fewer B cells than controls
• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice with levels dropping between 6 and 12 months of age
• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present in mice at 6 months of age

hematopoietic system
• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
• mice have 2.4-fold fewer B cells than controls
• spleen has 1.6-fold fewer B cells than controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory