Phenotypes Associated with This Genotype

Genotype
MGI:3836918

• Allelic Composition: Trip11^{Gt(AJ0490)Wtsi}/Trip11^{Gt(AJ0490)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Omphalocele and cardiovascular and lung defects in Trip11^{Gt(AJ0490)Wtsi}/Trip11^{Gt(AJ0490)Wtsi} mice

mortality/aging

neonatal lethality, complete penetrance ( J:142875 )

• while normal Mendelian ratios are present at E18.5, mice do not survive past P0

respiratory system

abnormal lung vasculature morphology ( J:142875 )

• lung capillaries are less associated with saccules compared to in wild-type mice

abnormal lung saccule morphology ( J:142875 )

• at E18.5, mice exhibit smaller saccules with thicker inter-saccule mesenchyme compared to in wild-type mice

• saccules occupy one third of the lung space compared to in wild-type mice

small lung saccule ( J:142875 )

abnormal pulmonary alveolus epithelial cell morphology ( J:142875 )

• type II surfactant cells are not clearly interdigited between type I cells and SFTPC (SP-C) staining is more punctate and distributed throughout the cells instead of localized to the apical end as in wild-type mice

abnormal type I pneumocyte morphology ( J:142875 )

• less flattened compared to in wild-type mice

cardiovascular system

abnormal lung vasculature morphology ( J:142875 )

• lung capillaries are less associated with saccules compared to in wild-type mice

overriding aortic valve ( J:142875 )

• at E18.5, one mouse exhibited VSD in conjunction with an overriding aorta and accompanied by narrowing of the pulmonary outflow tract and thickening of the ventricular chamber wall

muscular ventricular septal defect ( J:142875 )

• at E18.5, mice exhibit muscular ventricular septal defects (VSDs) in the anterior and posterior walls

• at E18.5, one mouse exhibited VSD in conjunction with an overriding aorta and accompanied by narrowing of the pulmonary outflow tract and thickening of the ventricular chamber wall

heart right ventricle outflow tract stenosis ( J:142875 )

• at E18.5, one mouse exhibited VSD in conjunction with an overriding aorta and accompanied by narrowing of the pulmonary outflow tract and thickening of the ventricular chamber wall

thick ventricular wall ( J:142875 )

• at E18.5, one mouse exhibited VSD in conjunction with an overriding aorta and accompanied by narrowing of the pulmonary outflow tract and thickening of the ventricular chamber wall

growth/size/body

omphalocele ( J:142875 )

• in some mice

decreased fetal weight ( J:142875 )

• at E18.5, mice weight 70% of normal

cellular

abnormal cell morphology ( J:142875 )

• mouse embryonic kidney cells exhibit cilia that are two-thirds as long as on wild-type cells

craniofacial

abnormal craniofacial morphology ( J:142875 )

• mice are usually born with open mouths and protruding tongue unlike wild-type mice indicating craniofacial anomalies

homeostasis/metabolism

cyanosis ( J:142875 )

• from birth to death

behavior/neurological

decreased locomotor activity ( J:142875 )

• at birth, mice are inactive but occasionally convulse or grasp