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Phenotypes Associated with This Genotype
Genotype
MGI:3836901
Allelic
Composition
Tg(ACTB-Peo1*)DSuom/0
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal aging and life span

cellular
• deletions in mitochondrial DNA accumulate unlike in wild-type mice
• deletions in mitochondrial DNA accumulate unlike in wild-type mice
• at 18 months, mice exhibit COX-SDH+, markers of decreased respiratory function and increased proliferation, muscles and brain cells unlike wild-type mice
• at 18 months, mice exhibit COX-SDH+, markers of decreased respiratory function and increased proliferation, muscles and brain cells unlike wild-type mice

muscle
N
• despite mitochondrial defects, mice exhibit normal muscle strength and performance
• at 18 months, muscle fibers exhibit an increase in the number and size of mitochondria compared to in wild-type mice
• severely affected muscle fibers exhibit large mitochondria with concentric cristae and electron-dense inclusions unlike in wild-type mice
• however, total respiration capacity of the muscle is normal
• at 18 months, mice exhibit COX-SDH+, markers of decreased respiratory function and increased proliferation, muscles cells unlike wild-type mice

nervous system
• at 18 months, 1% of Purkinje cells in the cerebellum and a few neurons in the olfactory bulbs, substantia nigra, and hypothalamus are COX-SDH+ unlike in wild-type mice that have no COX-SDH+ brain cells

homeostasis/metabolism
• deletions in mitochondrial DNA accumulate unlike in wild-type mice

behavior/neurological
N
• despite mitochondrial defects, mice exhibit normal muscle strength and performance


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory