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Phenotypes Associated with This Genotype
Genotype
MGI:3836731
Allelic
Composition
Egr2tm2Jmi/Egr2tm2Jmi
Genetic
Background
B6.Cg-Egr2tm2Jmi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2Jmi mutation (0 available); any Egr2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between P18 and P21

nervous system
• at P14, Schwann cell nuclei are irregularly shaped
• Schwann cells do not progress beyond the promyelinating phase and continue to proliferate unlike wild-type cells
• at P18, mice exhibit extensive sprouting at the neuromuscular junctions unlike in wild-type mice
• however, no abnormal sprouting is observed at P14
• the nodal structure of the sciatic nerve is abnormal
• at P14, the number of myelinating profiles is decreased, large caliber axons have no myelin sheaths, and myelin sheaths observed are thinner than in wild-type mice
• however, there is no evidence of demyelination or remyelination
• between P18 and P21 with evidence of conduction block

behavior/neurological
• mild at P14
• mice exhibit weakness in the hindlimbs at P14 and weakness in the forelimbs at P18 unlike wild-type mice
• at P14, mice exhibit slowness and gait abnormality unlike wild-type mice
• within 4 to 7 days of P14 mice exhibit weakness leading to hindlimb paralysis unlike wild-type mice

growth/size/body
• after P14

respiratory system

integument
N
• skin histology is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 4E DOID:0110195 OMIM:605253
J:145949


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory