Phenotypes Associated with This Genotype

Genotype
MGI:3836437

• Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe; Tg(VAV1-cre)1Graf/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:145700 )

• increased numbers of CFU-G and CFU-GEMM can be derived from E15.5 fetal livers compared to controls

increased granulocyte number ( J:145700 )

• numbers are increased almost 3-fold

abnormal platelet morphology ( J:145700 )

• increased numbers of CFU-G and CFU-GEMM can be derived from E15.5 fetal livers compared to controls

decreased lymphocyte cell number ( J:145700 )

• lymphocyte numbers are reduced by about a third

decreased thymocyte number ( J:145700 )

• there is about a 10-fold reduction in thymocyte number

decreased double-positive T cell number ( J:145700 )

• numbers in the thymus are decreased by half

decreased B cell number ( J:145700 )

• B cell numbers are greatly reduced

increased monocyte cell number ( J:145700 )

• numbers are increased over 2-fold

increased hematopoietic stem cell number ( J:145700 )

• lin^- Sca-1⁺ kit⁺ cell numbers in the bone marrow are increased about 5 fold

• increased numbers of CFU-C can be derived from E15.5 fetal livers compared to controls

• the vast majority of the CFUs have both alleles of the Runx1 gene deleted

immune system

increased granulocyte number ( J:145700 )

• numbers are increased almost 3-fold

decreased lymphocyte cell number ( J:145700 )

• lymphocyte numbers are reduced by about a third

decreased thymocyte number ( J:145700 )

• there is about a 10-fold reduction in thymocyte number

decreased double-positive T cell number ( J:145700 )

• numbers in the thymus are decreased by half

decreased B cell number ( J:145700 )

• B cell numbers are greatly reduced

increased monocyte cell number ( J:145700 )

• numbers are increased over 2-fold

endocrine/exocrine glands

decreased thymocyte number ( J:145700 )

• there is about a 10-fold reduction in thymocyte number