Phenotypes Associated with This Genotype

Genotype
MGI:3836426

• Allelic Composition: Aurka^tm1.2Tvd/Aurka^tm1.2Tvd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:145744 )

• embryos die shortly after the blastocyst stage

embryo

abnormal preimplantation embryo development ( J:145744 )

• at E3.5 embryos have about 3 fold fewer cells compared to control littermates

failure of blastocyst to hatch from the zona pellucida ( J:145744 )

• many cultured E3.5 embryos fail to hatch although in vivo some embryos do successfully hatch

cellular

abnormal mitotic spindle morphology ( J:145744 )

• cells from E3.5 embryos display monopolar spindles

increased mitotic index ( J:145744 )

• at E3.5 the mitotic index is about 8 fold higher compared to control littermates