About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3836158
Allelic
Composition
Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-AURKA)#Cxd mutation (0 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

integument
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:145680


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory