Mouse Genome Informatics
cx
    Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+

involves: 129S2/SvPas * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele (J:145680)
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)

integument
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele (J:145680)
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:145680