About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3836158
Allelic
Composition
Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-AURKA)#Cxd mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

integument
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:145680


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory