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Phenotypes Associated with This Genotype
Genotype
MGI:3836157
Allelic
Composition
Tg(MMTV-AURKA)#Cxd/?
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

neoplasm
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
• is noted in about 3% of mice that have given birth at least 5 times
• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching
• mammary glands are visibly larger at 4 month of age
• parous mice over one year in age have increased alveolization within the gland
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls
• is noted in about 3% of mice that have given birth at least 5 times

reproductive system
• is noted in about 3% of mice that have given birth at least 5 times
• is observed in mice that have given birth multiple times

integument
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
• parous mice over one year in age have more extensive ductal branching
• mammary glands are visibly larger at 4 month of age
• parous mice over one year in age have increased alveolization within the gland
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:145680


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory