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Phenotypes Associated with This Genotype
Genotype
MGI:3835423
Allelic
Composition
Tg(C3-1-TAg)cJeg/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(C3-1-TAg)cJeg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• some mice exhibit mixed tumors of the sweat glands and occasional nasal proliferative or neoplastic lesions develop from the nasal turbinate epithelium unlike in wild-type mice
• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)
• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)
• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)
• adenocarcinomas are classified as Dunn type B tumors (J:52786)
• adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)
• at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice
• at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)
• however, no metastasis is observed (J:46513)
(J:52786)
• at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)
• at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)
• PIN lesions increase with age (J:46513)
• at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)
• low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)
• at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)
• high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)
• numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral glands unlike in wild-type mice

endocrine/exocrine glands
• 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age
• 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age
• acini lesions resemble hyperplastic alveolar nodules
• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)
• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)
• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)
• adenocarcinomas are classified as Dunn type B tumors (J:52786)
• adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)
• at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice
• hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice
• hyperplastic changes in the epithelium of the dorsal/ventral regions of the prostate are seen as early as 3 months of age
• at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice
• at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)
• however, no metastasis is observed (J:46513)
(J:52786)
• at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)
• at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)
• PIN lesions increase with age (J:46513)
• at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)
• low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)
• at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)
• high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)
• numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

reproductive system
• hyperplastic changes in the epithelium of the dorsal/ventral regions of the prostate are seen as early as 3 months of age
• at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)
• however, no metastasis is observed (J:46513)
(J:52786)
• at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)
• at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)
• PIN lesions increase with age (J:46513)
• at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)
• low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)
• at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)
• high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)
• numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)
• the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)
• prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

integument
• 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age
• 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age
• acini lesions resemble hyperplastic alveolar nodules
• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)
• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)
• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)
• adenocarcinomas are classified as Dunn type B tumors (J:52786)
• adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)
• at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice
• hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice

mortality/aging
• survival of males is longer than females, with 50% survival at around 4 months of age for females and 8 months of age for males
• all females die by 5-6 months of age, while all males die by 11 months of age

renal/urinary system
• at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice
• at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral glands unlike in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory