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Phenotypes Associated with This Genotype
Genotype
MGI:3835361
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(NES-TVA)J12Ech/0
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (56 available)
Tg(NES-TVA)J12Ech mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)
• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice
• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation
• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB
• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

mortality/aging
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 15% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice (J:125535)
• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in improved survival compared to mice infected with RCAS-PDGFB alone (J:153220)

neoplasm
• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)
• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice
• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation
• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB
• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:153220


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory