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Phenotypes Associated with This Genotype
Genotype
MGI:3834658
Allelic
Composition
TcraLn3Jae/Tcra+
Genetic
Background
B6.Cg-TcraLn3Jae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TcraLn3Jae mutation (0 available); any Tcra mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cellularity of the thymus is reduced by more than 5-fold
• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4
• however, there is a large population of unusual double-negative thymocytes that are CD3+
• this double-negative CD3+ population is found abundantly in the spleen making up 31% of the splenocyte population
• there is about a 2-fold reduction in the percentage of double-positive thymocytes
• the percentage of CD4+ T cells in the spleen is reduced to less than a third of that in wild-type
• there is a 2-fold increase in the percentage of CD8+ single positive thymocytes

hematopoietic system
• cellularity of the thymus is reduced by more than 5-fold
• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4
• however, there is a large population of unusual double-negative thymocytes that are CD3+
• this double-negative CD3+ population is found abundantly in the spleen making up 31% of the splenocyte population
• there is about a 2-fold reduction in the percentage of double-positive thymocytes
• the percentage of CD4+ T cells in the spleen is reduced to less than a third of that in wild-type
• there is a 2-fold increase in the percentage of CD8+ single positive thymocytes

endocrine/exocrine glands
• cellularity of the thymus is reduced by more than 5-fold


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory