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Phenotypes Associated with This Genotype
Genotype
MGI:3834639
Allelic
Composition
Pirttm1Xzd/Pirttm1Xzd
Genetic
Background
B6.129-Pirt1tm1Xzd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirttm1Xzd mutation (0 available); any Pirt mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• using capsaicin but not mustard oil regardless of inflammatory state
• at 48, 50, and 52.5 degrees Celsius using a tail immersion test and at 50 and 52.5 degrees Celsius using a hot plate test

nervous system
• dorsal root ganglion nerves responding to noxious heat and capsaicin exhibit a smaller response than in wild-type mice with reduced current over capacitance values
• bradykinin-mediated TRPV1 potentiation is reduced compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory