About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3834483
Allelic
Composition
Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg/0
Genetic
Background
involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die by 18 months of age
• only 23% of ganciclovir-treated mice die during treatment

neoplasm
• all mice develop chronic myeloid leukemia by 6 to 10 months of age with progression to blast crisis
• however, treatment with ganciclovir reduced the number of mice that develop tumors and cures chronic myeloid leukemia in sick mice
• however, Sca1+Lin- cells from ganciclovir-treated mice fail to cause leukemia when engrafted into an irradiated wild-type mouse

immune system
• mice exhibit increased white blood cell count compared to in wild-type mice
• however, treatment with ganciclovir can restore white blood cell counts to normal

hematopoietic system
• mice exhibit increased white blood cell count compared to in wild-type mice
• however, treatment with ganciclovir can restore white blood cell counts to normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:144382


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/17/2019
MGI 6.14
The Jackson Laboratory