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Phenotypes Associated with This Genotype
Genotype
MGI:3834482
Allelic
Composition
Tg(Ly6a-BCR/ABL1)IS1BIsg/0
Genetic
Background
involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Sertoli cell tumors develop in 2% of mice

endocrine/exocrine glands
• Sertoli cell tumors develop in 2% of mice

skeleton

mortality/aging
• mice die by 18 months of age
• 30% of mice die due to kidney failure from myeloid infiltrates in the kidney
• 70% of mice die from progression to blast crisis
• treatment with STI571 does not alter survival

neoplasm
• Sertoli cell tumors develop in 2% of mice
• 3% of mice develop hepatocarcinoma
• all mice develop chronic myeloid leukemia by 4 to 10 months of age with progression to blast crisis
• myeloid and lymphoid blasts appear in the peripheral blood, bone marrow, spleen, and liver
• leukemia can be induced in wild-type mice by engraftment of Sca+Lin- cells but not Sca-Lin+ cells

immune system
• spleens contain megakaryocyte as markers of myeloid metaplasia
• spleens contain megakaryocyte as markers of myeloid metaplasia
• contains myeloid cells

cellular
• centromere abnormalities are detected in 24% chronic phase cells and 62% of acute phase cells compared to 3% of wild-type cells

liver/biliary system
• livers contain megakaryocyte as markers of myeloid metaplasia
• 3% of mice develop hepatocarcinoma

renal/urinary system
• 30% of mice die due to kidney failure from myeloid infiltrates in the kidney

respiratory system
• contains myeloid cells

hematopoietic system
• spleens contain megakaryocyte as markers of myeloid metaplasia
• spleens contain megakaryocyte as markers of myeloid metaplasia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:144382


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory