About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3834442
Allelic
Composition
Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-PIK3CA*H1047R)13Lca/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-rtTA)1Jaw mutation (3 available)
Tg(tetO-PIK3CA*H1047R)13Lca mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• at 12 weeks following doxycycline treatment, mice develop lung adenocarcinomas
• however, withdrawal of doxycycline or treatment with NVP-BEZ235 leads to tumor regression

neoplasm
• at 12 weeks following doxycycline treatment, mice develop lung adenocarcinomas
• however, withdrawal of doxycycline or treatment with NVP-BEZ235 leads to tumor regression

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:142254


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory