Phenotypes Associated with This Genotype

Genotype
MGI:3834442

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-PIK3CA*H1047R)13Lca/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:142254 )

• at 12 weeks following doxycycline treatment, mice develop lung adenocarcinomas

• however, withdrawal of doxycycline or treatment with NVP-BEZ235 leads to tumor regression

respiratory system

increased lung adenocarcinoma incidence ( J:142254 )

• at 12 weeks following doxycycline treatment, mice develop lung adenocarcinomas

• however, withdrawal of doxycycline or treatment with NVP-BEZ235 leads to tumor regression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:142254