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Phenotypes Associated with This Genotype
Genotype
MGI:3832595
Allelic
Composition
Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0
Genetic
Background
involves: C3H * C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 females exhibit ovarian surface epithelium hyperplasia

reproductive system
• half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age
• reduced number of follicles

neoplasm
N
• despite detection of AMHR2 activation in human ovarian cancer, no epithelial ovarian tumors are detected

endocrine/exocrine glands
• half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age
• reduced number of follicles

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Ovarian Cancer 167000 J:144834


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory