Mouse Genome Informatics
tg
    Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0
involves: C3H * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 females exhibit ovarian surface epithelium hyperplasia

reproductive system
• half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age
• reduced number of follicles

tumorigenesis
N
• despite detection of AMHR2 activation in human ovarian cancer, no epithelial ovarian tumors are detected

endocrine/exocrine glands
• half show hyperplasia in the ovarian surface epithelium by 4 months of age and all show hyperplasia by 10 months of age
• reduced number of follicles

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Ovarian Cancer 167000 J:144834