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Phenotypes Associated with This Genotype
Genotype
MGI:3832577
Allelic
Composition
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas mutation (0 available); any Gt(ROSA)26Sor mutation (315 available)
Tg(Ins2-cre)23Herr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduction in islet insulin content in Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+ Tg(Ins2-cre)23Herr/0 mice

endocrine/exocrine glands
• the percentage of islet area occupied by beta cells is somewhat decreased
• alpha cells are not confined to the islet mantle
• relative increase in the number of alpha cells
• some of the beta cells are irregularly shaped
• the percentage of beta cells is decreased
• reduction in islet insulin content by 5 weeks of age but not at 5 days of age
• K(sub)ATP currents in beta cells are larger compared to control cells an inhibition of these currents by glucose is impaired
• glucose induced calcium responses of beta cells are impaired
• impairment in basal and both first and second-phase glucose induced insulin secretion

homeostasis/metabolism
• impairment in basal and both first and second-phase glucose induced insulin secretion
• elevated glucose levels develop by P3
• overt diabetes develops by 5 weeks of age

growth/size/body
• seen in males by 4 to 6 weeks of age

renal/urinary system
• produce copious amounts of urine after when a few weeks old

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Permanent Neonatal; PNDM 606176 J:144715


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory