Phenotypes Associated with This Genotype

Genotype
MGI:3832407

• Allelic Composition: Slc6a1^tm1Mlit/Slc6a1^tm1Mlit
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:144919 )

• mice have lower body weights but gradually normalize by 3-4 months of age

taste/olfaction

abnormal bitter taste sensitivity ( J:144919 )

• mice demonstrate an increased aversion than controls to water containing 0.03 mM or higher quinine

behavior/neurological

abnormal behavioral response to xenobiotic ( J:144919 )

• when a large dose (3.6 g/kg bodyweight) of ethanol is used as an anesthetic, mice exhibit significantly more tolerance to the sedative effects

• the time to regain righting reflex after ethanol administration is 51 minutes compared to 87 minutes for controls

abnormal conditioned taste aversion behavior ( J:144919 )

• mice have significantly reduced conditioned taste aversion for ethanol than do controls

increased startle reflex ( J:144919 )

• mice have a nervous-like behavior

tremors ( J:144919 )

• mice have strong body tremors when picked up or when encountering novel stimuli

ataxia ( J:144919 )

• is noted in these mice

hyperactivity ( J:144919 )

• mice have increased activity compared to controls