Phenotypes for Stx1a Stx1b MGI:3832394 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud Stx1b^tm1.1Sud/Stx1b^tm1.1Sud
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx1a^tm2.1Sud mutation (0 available); any Stx1a mutation (25 available)
Stx1b^tm1.1Sud mutation (1 available); any Stx1b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:138035 )

• a 20% increase in size of the postsynaptic density is observed compared to cultured cortical neurons with wild type Stx1a

abnormal synaptic vesicle recycling ( J:138035 )

• about a 25% increase in synaptic vesicle docking at synapses in cultured cortical neurons compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23