Phenotypes for Foxa1 Foxa2 Tg(Pdx1-cre)6Cvw MGI:3831162 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Foxa1^tm1Khk/Foxa1⁺ Foxa2^tm1Khk/Foxa2^tm1Khk Tg(Pdx1-cre)6Cvw/0
Genetic Background	involves: 129 * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa1^tm1Khk mutation (0 available); any Foxa1 mutation (20 available)
Foxa2^tm1Khk mutation (1 available); any Foxa2 mutation (26 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:143476 )

• mice die prior to P5

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:143476 )

pancreatic islet hypoplasia ( J:143476 )

pancreas hypoplasia ( J:143476 )

• the pancreas occupies 31% relative area compared to in wild-type mice

exocrine pancreas hypoplasia ( J:143476 )

digestive/alimentary system

exocrine pancreas hypoplasia ( J:143476 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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