Phenotypes Associated with This Genotype

Genotype
MGI:3830991

• Allelic Composition: Bub1^tm1.1Tvd/Bub1^tm1.1Tvd
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:143035 )

• only 20% of expected mice from the fourth generation on this background are alive at birth unlike on a congenic FVB background in which mice survive normally or on a congenic C57BL/6 background in which nearly all mice die perinatally

cellular

aneuploidy ( J:143035 )

• 76% of mouse embryonic fibroblasts exhibit aneuploidy compared to 9% of wild-type cells

abnormal cell cycle ( J:143035 )

• mouse embryonic fibroblast cells exhibit increases in spindle assembly and chromosome congression defects compared to wild-type cells

abnormal cell cycle checkpoint function ( J:143035 )

• nocodazole-treated mouse embryonic fibroblasts exhibit only a modestly lower increase in mitotic index compared to similarly treated wild-type cells

abnormal mitotic spindle assembly checkpoint ( J:143035 )

• taxol-treated mouse embryonic fibroblasts exhibit severe defects in spindle assembly checkpoints compared to in similarly treated wild-type cells

abnormal mitotic spindle morphology ( J:143035 )

• mouse embryonic fibroblast cells exhibit increases in spindle assembly defects

decreased fibroblast proliferation ( J:143035 )

• mouse embryonic fibroblasts exhibit impaired growth compared to wild-type cells

early cellular replicative senescence ( J:143035 )

• mouse embryonic fibroblasts exhibit higher rates of senescence compared to wild-type cells

neoplasm

increased liver tumor incidence ( J:143035 )

• the majority of tumors are of liver origins

increased incidence of induced tumors ( J:143035 )

• 76% of mice develop tumors by 23 to 25 months of age compared to 28% of wild-type mice

increased lung tumor incidence ( J:143035 )

• 16% of mice develop lung tumors compared to no wild-type mice

liver/biliary system

increased liver tumor incidence ( J:143035 )

• the majority of tumors are of liver origins

respiratory system

increased lung tumor incidence ( J:143035 )

• 16% of mice develop lung tumors compared to no wild-type mice