mortality/aging
• 75% of mice die before P7
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nervous system
• presynaptic long-term plasticity is abolished unlike in wild-type mice
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• miniature inhibitory postsynaptic current (mIPSC) frequency is decreased compared to in wild-type mice
• reduction in mIPSC is more severe than in Rims1tm1Sud homozygotes
• evoked inhibitory postsynaptic current (eIPSC) amplitude is reduced compared to in wild-type mice
• reduction in eIPSC is more severe than in Rims1tm1Sud homozygotes
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• paired pulse depression is decreased compared to in wild-type mice that is more pronounced than in Rims1tm1Sud homozygotes
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