Mouse Genome Informatics
hm
    Ncor2tm1Rev/Ncor2tm1Rev
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• increase in circulating thrombopoietin levels
• serum concentrations of the osteoclast-specific tartrate-resistant acid phosphatase are increased
• when resting or active
• mice expend 20% less energy than wild-type mice
• respiratory rates are decreased compared to in wild-type mice
• the respiratory exchange ratio is reduced compared to in wild-type mice
• baseline hepatic glucose production is higher than in wild-type mice
• insulin-stimulated glucose disposal is diminished compared to in wild-type mice
• mice exhibit decreased metabolic rates compared to in wild-type mice
• mice treated with propylthiouracil/methimazole to render them hypothyroid exhibit decreased hypercholesterolemia compared to similarly treated wild-type mice
• seen by 8 months of age

adipose tissue
N
• despite increased fat content, adipocyte size is normal (J:142665)
• when fed a standard or high fat diet
• when fed a standard or high fat diet, epididymal fat pad to body weight ratio is increased 70% compared to in wild-type mice

growth/size/body
• when fed a standard or high fat diet
• mice are 10% lighter than wild-type mice

cellular
• 100% of mouse embryonic fibroblasts (MEFs) can be induced to differentiate into adipose cells compared to 5% of wild-type cells
• some MEFs undergone spontaneous differentiation into adipose cells unlike wild-type cells

cardiovascular system
• at birth mice exhibit a thin ventricular wall compared to in wild-type mice
• however, by adulthood hearts morphology is normal

nervous system
N
• unlike mice homozygous for a null allele, brain development is normal (J:142665)

behavior/neurological
• hind limb paresis by 8 months of age

hematopoietic system
• about 25% increase in overall osteoclast numbers, however osteoblast activity is not affected
• increase in osteoclast numbers along the endosteal surface
• extramedullary hematopoiesis is evident in the enlarged spleen
• decrease in hematopoietic progenitors in the bone marrow
• increase in nonhematopoietic cells in the bone marrow, with much of the marrow cavity occupied by reticular cells and collagen fibers
• increase in splenic hematopoietic progenitors with a concurrent decrease of hematopoietic progenitors in the bone marrow
• increase in splenic hematopoietic progenitors
• by 8 months of age, mice show splenomegaly

immune system
• about 25% increase in overall osteoclast numbers, however osteoblast activity is not affected
• increase in osteoclast numbers along the endosteal surface
• increase in splenic hematopoietic progenitors
• by 8 months of age, mice show splenomegaly

skeleton
• about 25% increase in overall osteoclast numbers, however osteoblast activity is not affected
• increase in osteoclast numbers along the endosteal surface
• bone marrow cavities from 8 month old mice contain large amounts of small spicules and increased numbers of CD34+ microvessels
• 100% increase in levels of thrombopoietin in the bone marrow
• seen by 8 months of age
• cortical thinning without significant differences in cortical bone density
• increase in bone volume in trabecular regions, with a decrease in trabecular bone spacing and increase in trabecular bone numbers
• seen by 8 months of age
• reduction in radial growth without any significant differences in length
• about 20% reduction in fracture load when mice are subjected to a femoral neck fracture assay

Mouse Models of Human Disease
OMIM IDRef(s)
Myelofibrosis 254450 J:202976