Phenotypes Associated with This Genotype

Genotype
MGI:3829439

• Allelic Composition: Crtc1^Gt(XK522)Byg/Crtc1^Gt(XK522)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent corpus luteum ( J:142448 )

♀ • ovaries contained no corpora lutea

♀ • ovaries had comparable numbers of follicles

thin uterus ( J:142448 )

♀ • uteri appeared thread-like with noticeable thinning of the endometrium

female infertility ( J:142448 )

♀ • mice were infertile, and no offspring were obtained from homozygous male or females mated with wild-type mice

male infertility ( J:142448 )

♂ • mice were infertile, and no offspring were obtained from homozygous male or females mated with wild-type mice

endocrine/exocrine glands

absent corpus luteum ( J:142448 )

♀ • ovaries contained no corpora lutea

♀ • ovaries had comparable numbers of follicles

homeostasis/metabolism

hyperglycemia ( J:142448 )

• by 9 months of age on normal chow diet

decreased circulating luteinizing hormone level ( J:142448 )

• circulating concentrations of pituitary luteinizing hormone were reduced

increased circulating insulin level ( J:142448 )

• by 9 months of age on normal chow diet

increased circulating triglyceride level ( J:142448 )

• by 9 months of age on normal chow diet

decreased energy expenditure ( J:142448 )

• at 12-14 weeks of age on normal chow diet

impaired glucose tolerance ( J:142448 )

• by 9 months of age on normal chow diet

growth/size/body

obese ( J:142448 )

• developed persistent obesity beginning at 9 weeks of age on a normal chow diet

• linear growth was unimpaired and they were indistinguishable from controls before weaning

adipose tissue

increased white adipose tissue amount ( J:142448 )

• white adipose mass was increased two- to threefold

• other tissues were unaffected

behavior/neurological

polyphagia ( J:142448 )

• at 12-14 weeks of age on normal chow diet