Phenotypes Associated with This Genotype

Genotype
MGI:3829003

• Allelic Composition: Macf1^tm1Efu/Macf1^tm1Efu; Tg(KRT14-cre)1Efu/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

delayed wound healing ( J:143595 )

• areas of hyperproliferating epithelium at wound sites are decreased by more than 30% over 2 to 4 days after injury compared to in similarly treated wild-type mice

• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells

integument

increased keratinocyte adhesion ( J:143595 )

• keratinocytes exhibit stronger focal adhesions in culture than wild-type cells

decreased keratinocyte migration ( J:143595 )

• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells

• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells

• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal

cellular

increased keratinocyte adhesion ( J:143595 )

• keratinocytes exhibit stronger focal adhesions in culture than wild-type cells

decreased keratinocyte migration ( J:143595 )

• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells

• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells

• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal