Mouse Genome Informatics
hm
    Pde6anmf363/Pde6anmf363
C57BL/6J-Pde6anmf363
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• degradation of the outer segment is observed at P19
• however, dark-rearing mice on a pure C57BL/6J background slows the progression of photoreceptor degeneration
• at P14, the outer nuclear layer is reduced in thickness by 30% compared to in wild-type mice
• Background Sensitivity: at P19, dark-reared mice on a C57BL/6J background exhibit reduced outer nuclear layer thickness compared to in wild-type mice that is not as severe as in homozygotes raised in standard lighting conditions
• at P30, a single layer of cell bodies remains in the outer nuclear layer
• however, dark-reared mice on a pure C57BL/6J background exhibit normal retinal outer nuclear layer thickness at P14
• some residual activity is measured at P21
• Background Sensitivity: when mice are on a pure C57BL/6J background, a and b waves in dark-reared homozygotes are larger than mice reared under standard light conditions but smaller than in wild-type mice

nervous system
• degradation of the outer segment is observed at P19
• however, dark-rearing mice on a pure C57BL/6J background slows the progression of photoreceptor degeneration

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa; RP 268000 J:142108