About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3828076
Allelic
Composition
Dock1tm1Jfco/Dock1tm1Jfco
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (129 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although present in Mendelian ratios at E18.5, all mice die prior to weaning

muscle
• at E14.5, muscle mass and myoblast fusion are decreased compared to in wild-type mice
• in culture, myoblasts are unable to form long nucleated fibers after 4 days unlike wild-type cells
• however, myoblast differentiation and migration of muscle progenitors are normal
• at E12.5, E13.5 and E18.5, the diameter of muscle fibers is decreased compared to in wild-type mice
• at E14.5 and E16.5, the attachment of the diaphragm to the intercostal muscles is severely impaired
• at E14.5, and E16.5
• intercostal muscles are reduced in size leading to ribs stacked closer together than in wild-type mice
• at E16.5 and E18.5, the size of deep back muscles, tongue and limb muscles is reduced compared to in wild-type mice
• at E13.5, apoptosis of myofibers is increased compared to in wild-type mice

respiratory system
• lungs do not inflate

growth/size/body
• at birth, mice are smaller than normal and fail to straighten

homeostasis/metabolism
• within minutes of birth


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory