Analysis Tools
cardiovascular system
| N |
• despite the increase in heart size, cardiac function at 1 year of age is similar to controls
|
|
• at E13.5 a 30% increase in BrdU incorporation is seen in hearts
|
|
• increased heart weight relative to body weight compared to controls
|
|
• analysis suggests increased heart size is due to increased cellularity not an increase in cell size
|
|
• myocyte hypertrophy in response to transverse aortic constriction is reduced compared to controls
• results from long term transverse aortic constriction suggest homozygotes are partially protected from long term pressure overload induced dysfunction
• reduced decompensation at 4 weeks after permanent ligation of the left coronary artery
|
|
• following permanent ligation of the left coronary artery the degree of infarct expansion is reduced compared to controls
|
cellular
|
• reduced susceptibility to staurosporine induced apoptosis
|
hematopoietic system
|
• increased spleen weight relative to body weight compared to controls
|
homeostasis/metabolism
|
• myocyte hypertrophy in response to transverse aortic constriction is reduced compared to controls
• results from long term transverse aortic constriction suggest homozygotes are partially protected from long term pressure overload induced dysfunction
• reduced decompensation at 4 weeks after permanent ligation of the left coronary artery
|
|
• following permanent ligation of the left coronary artery the degree of infarct expansion is reduced compared to controls
|
immune system
|
• increased spleen weight relative to body weight compared to controls
|
muscle
| N |
• at 2 months, untreated mice exhibit normal skeletal muscle tissue morphology
|
|
• moderate in untreated mice
• 2.4-fold increase in self-renewed satellite cells following cardiotoxin treatment
• 2-fold increase in quiescent sublaminar Pax7+ satellite cells following cardiotoxin treatment
• however, the number of quiescent sublaminar Pax7+ satellite cells is number in untreated mice
|
|
• at 2 months, satellite cells exhibit impaired ability to return to quiescence compared with control cells
|
growth/size/body
|
• increased heart weight relative to body weight compared to controls
|
|
• analysis suggests increased heart size is due to increased cellularity not an increase in cell size
|
|
• increased spleen weight relative to body weight compared to controls
|
