Phenotypes Associated with This Genotype

Genotype
MGI:3826863

• Allelic Composition: Arg1^tm1Pmu/Arg1^tm1Pmu; Tg(Tek-cre)1Ywa/?
• Genetic Background: B6.Cg-Tg(Tek-cre)1Ywa Arg1^tm1Pmu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:143229 )

• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity

increased macrophage nitric oxide production ( J:143229 )

• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection

decreased susceptibility to bacterial infection ( J:143229 )

• mice infected with M. tuberculosis have lower bacterial counts than wild-type littermates in the lungs after the initial bacterial growth period

• there is also lower bacterial load in the spleens of the mice 70 days after infection with M. tuberculosis

• lung granulomas in these infected mice occupy a smaller fraction of the total lung area and have a more pronounced lymphocytic infiltrate

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:143229 )

• there is more NO activity in liver granulomas of mice infected with M. tuberculosis

increased macrophage nitric oxide production ( J:143229 )

• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection

hematopoietic system

abnormal macrophage physiology ( J:143229 )

• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity

increased macrophage nitric oxide production ( J:143229 )

• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection