Mouse Genome Informatics
tg
    Tg(RNU6-RNAi:Cldn16)551Dago/0
involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• at 14 to 16 weeks of age, mice exhibit 28% lower plasma magnesium levels than in wild-type mice
• plasma potassium levels are 17% lower than in wild-type mice
• fractional excretion of potassium is 2-fold more than in wild-type mice
• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice

renal/urinary system
• fractional excretion of potassium is 2-fold more than in wild-type mice
• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 6 months, mice exhibit calcium deposits in the basement membrane of the medullary tubules and the surrounding interstitium unlike in wild-type mice

cardiovascular system

skeleton
• when fed a calcium poor diet, mice exhibit a decrease in bone mineral content compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral content on a standard diet
• when fed a calcium poor diet, mice exhibit a decrease in bone mineral density compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral density on a standard diet

Mouse Models of Human Disease
OMIM IDRef(s)
Hypomagnesemia 3, Renal; HOMG3 248250 J:122766