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Phenotypes Associated with This Genotype
Genotype
MGI:3822351
Allelic
Composition
Tg(RNU6-RNAi:Cldn16)551Dago/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• at 14 to 16 weeks of age, mice exhibit 28% lower plasma magnesium levels than in wild-type mice
• plasma potassium levels are 17% lower than in wild-type mice
• fractional excretion of potassium is 2-fold more than in wild-type mice
• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice

renal/urinary system
• fractional excretion of potassium is 2-fold more than in wild-type mice
• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice
• at 6 months, mice exhibit calcium deposits in the basement membrane of the medullary tubules and the surrounding interstitium unlike in wild-type mice

cardiovascular system

skeleton
• when fed a calcium poor diet, mice exhibit a decrease in bone mineral content compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral content on a standard diet
• when fed a calcium poor diet, mice exhibit a decrease in bone mineral density compared to similarly treated wild-type mice
• however, mice exhibit normal bone mineral density on a standard diet

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
renal hypomagnesemia 3 DOID:0060880 OMIM:248250
J:122766


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory