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Phenotypes Associated with This Genotype
Genotype
MGI:3822320
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(S100b-v-erbB)4496Waw/0
Genetic
Background
involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (56 available)
Tg(S100b-v-erbB)4496Waw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

mortality/aging
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

neoplasm
• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma
• mice exhibit decreased latency of glioma development compared to Tg(S100b-v-erbB)4496Waw mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
oligodendroglioma DOID:3181 J:82649


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory