Phenotypes Associated with This Genotype

Genotype
MGI:3822315

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: involves: C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:164339 )

♀

absent estrus ( J:164339 )

♀

absent estrous cycle ( J:164339 )

female infertility ( J:142218 , J:164339 )

♀ (J:142218)

♀ (J:164339)

homeostasis/metabolism

impaired adaptive thermogenesis ( J:142218 )

• thermoregulation in response to cold exposure is severely impaired compared to wild-type controls

increased circulating glucose level ( J:164339 )

hyperglycemia ( J:142218 )

increased circulating insulin level ( J:164339 )

increased circulating leptin level ( J:142218 )

abnormal oxygen consumption ( J:142218 )

• oxygen consumption normalized to lean mass is increased compared to wild-type controls but oxygen consumption normalized to metabolic size is decreased compared to wild-type controls

impaired glucose tolerance ( J:142218 , J:164339 )

insulin resistance ( J:142218 , J:164339 )

growth/size/body

decreased lean body mass ( J:164339 )

increased body weight ( J:164339 )

obese ( J:142218 )

• early onset obesity starting from 4 weeks of age

decreased body length ( J:142218 , J:164339 )

adipose tissue

increased percent body fat/body weight ( J:142218 , J:164339 )

behavior/neurological

abnormal eating behavior ( J:164339 )

polyphagia ( J:142218 )

decreased locomotor activity ( J:142218 )

• decreased activity in both the light and dark cycle

limbs/digits/tail

short femur ( J:164339 )

skeleton

short femur ( J:164339 )