Phenotypes Associated with This Genotype

Genotype
MGI:3821728

• Allelic Composition: Dlgap5^tm1Tfts/Dlgap5^tm1Tfts
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:142315 )

N • ovarian function and fertilization are normal

N • males are fertile

abnormal decidualization ( J:142315 )

♀ • fail to show any signs of decidualization following artificial induction of the decidual reaction

♀ • endometrial stromal proliferation is severely impaired on days 4 and 5 of pregnancy as the result of a pre-mitotic block leading to impaired cell cycle progression

female infertility ( J:142315 )

♀ • females are infertile due to a defect in implantation

embryo

abnormal decidualization ( J:142315 )

♀ • fail to show any signs of decidualization following artificial induction of the decidual reaction

♀ • endometrial stromal proliferation is severely impaired on days 4 and 5 of pregnancy as the result of a pre-mitotic block leading to impaired cell cycle progression