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Phenotypes Associated with This Genotype
Genotype
MGI:3819453
Allelic
Composition
Tg(tetO-TAg,CMV-rtTA)123Yihu/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 22 of 24 doxycycline-induced mice develop medulloblastoma
• however, few un-induced mice develop brain tumors after 12 months of age

mortality/aging
• after two months of induction with doxycycline, 22 of 24 mice are moribund with medulloblastoma

neoplasm
• 22 of 24 doxycycline-induced mice develop medulloblastoma
• however, few un-induced mice develop brain tumors after 12 months of age

craniofacial
• at 2 months doxycycline-induced mice exhibit ridgy craniums unlike in wild-type mice

skeleton
• at 2 months doxycycline-induced mice exhibit ridgy craniums unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:141623


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory