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Phenotypes Associated with This Genotype
Genotype
MGI:3819135
Allelic
Composition
Nogtm1Amc/Nogtm1Amc
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nogtm1Amc mutation (2 available); any Nog mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryogenesis
• at E11.5 embryos show open brain phenotype
• at E11.5 caudal neural tube is open
• abnormal at E8.5 and E9, indicating delayed detachment from dorsal foregut endoderm; appears hypertrophic compared to wild-type at E9
• no clear boundary between notochord and endoderm is detected at E8.5
• at E9.5, notochord has lateral branches close to or tethered to dorsal foregut in contrast to wild-type notochord
• increased apoptotic cell numbers are seen at E9.5-E9.75
• non-notochordal cells are observed within the notochord at E9.0

digestive/alimentary system
• at E10.5-11.5 most mutants display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF); some embryos show milder phenotype indicative of esophageal stenosis
• at E9.5, reduction in dorsoventral diameter of the foregut is observed; dorsal foregut endoderm is reduced in mutant embryos
• loosening or loss of dorsal foregut cells is consistently observed at E9; endodermal cells show basement membrane disruption
• at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF)
• severe narrowing of the esophagus is seen by E9.5
• at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF) with the upper esophagus ending in a blind pouch and the lower esophagus connects to the trachea via a fistula

nervous system
• at E11.5 embryos show open brain phenotype
• at E11.5 caudal neural tube is open

respiratory system
• at E10.5-11.5, >80% of embryos display Type C esophageal atresia/tracheoesophageal fistula (EA/TEF) with the upper esophagus ending in a blind pouch and the lower esophagus connects to the trachea via a fistula


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory