Phenotypes Associated with This Genotype

Genotype
MGI:3818652

• Allelic Composition: Nr6a1^tm1Coo/Nr6a1^tm1Coo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67377 )

• decreased numbers of homozygotes after E10.5

• only resorbing homozygous embryos at E11.5

• normal ratio of homozygotes through E9.5

embryo

abnormal embryo development ( J:67377 )

• embryos severely malformed at E10.5

• the tailbud and the posterior of the embryo develop ectopically outside the yolk sac

abnormal developmental patterning ( J:67377 )

failure of initiation of embryo turning ( J:67377 )

caudal body truncation ( J:67377 )

• halt in somitogenesis after 13 somites leading to a posterior truncation

abnormal embryonic tissue morphology ( J:67377 )

• posterior protrusions outside of the yolk sac

abnormal neural tube closure ( J:67377 )

• neural tube remains open at E9.5; however, neural tube closure is observed in the middle of the ectopic tailbud

• anterior neural tissue continues to grow

abnormal caudal neuropore morphology ( J:67377 )

• no posterior neuropore is observed in the tailbud at E9.5

abnormal primitive streak morphology ( J:67377 )

• large invagination of neural epithelium within the primitive streak at E8.5

incomplete somite formation ( J:67377 )

• no more than 13 somites form

• reduced trunk and posterior structures at E9.5

abnormal extraembryonic tissue morphology ( J:67377 )

abnormal allantois morphology ( J:67377 )

• protrusion of tissue at the base of the allantois

• often fails to attach to the chorion

enlarged allantois ( J:67377 )

• often

abnormal chorion morphology ( J:67377 )

• often unattached to allantois

failure of chorioallantoic fusion ( J:67377 )

• allantois often fails to attach to the chorion

nervous system

abnormal neural tube closure ( J:67377 )

• neural tube remains open at E9.5; however, neural tube closure is observed in the middle of the ectopic tailbud

• anterior neural tissue continues to grow

abnormal caudal neuropore morphology ( J:67377 )

• no posterior neuropore is observed in the tailbud at E9.5

abnormal brain development ( J:108393 )

• increased apoptosis in the brain at E9.5

abnormal cranial nerve morphology ( J:108393 )

abnormal oculomotor nerve morphology ( J:108393 )

• poorly developed

abnormal trochlear nerve morphology ( J:108393 )

• poorly developed

digestive/alimentary system

abnormal hindgut morphology ( J:67377 )

• hindgut is poorly formed at E9.5

• remains open

cardiovascular system

distended pericardium ( J:67377 )

skeleton

abnormal spine curvature ( J:67377 )

• widened curvature of the spine at E8.5

growth/size/body

abnormal ventral body wall morphology ( J:67377 )

• ventral body wall is poorly developed at E9.5