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Phenotypes Associated with This Genotype
Genotype
MGI:3818532
Allelic
Composition
Coro1akoy/Coro1akoy
Genetic
Background
C57BL/6-Coro1akoy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coro1akoy mutation (1 available); any Coro1a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice
• CD4+ T cell numbers in the periphery are significantly decreased about 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased about 5-fold
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21

hematopoietic system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice
• CD4+ T cell numbers in the periphery are significantly decreased about 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased about 5-fold
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21

endocrine/exocrine glands
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory