Mouse Genome Informatics
hm
    Coro1akoy/Coro1akoy
C57BL/6-Coro1akoy
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• CD4+ T cell numbers in the periphery are significantly decreased about 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased about 5-fold
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21

hematopoietic system
• CD4+ T cell numbers in the periphery are significantly decreased about 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased about 5-fold
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is decreased in these mice
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21

Mouse Models of Human Disease
OMIM IDRef(s)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive 608971 J:141431