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Phenotypes Associated with This Genotype
Genotype
MGI:3818531
Allelic
Composition
Coro1aptcd/Coro1aptcd
Genetic
Background
B6.CTS-Coro1aptcd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coro1aptcd mutation (0 available); any Coro1a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls (J:141431)
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls (J:141431)
• CD4+ T cell numbers in the periphery are decreased around 10-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD4+ T cell numbers in the periphery are decreased around 10-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD8+ T cell numbers in the periphery are decreased around 5-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD8+ T cell numbers in the periphery are decreased around 5-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12 (J:141431)
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21 (J:141431)
• mutant T cells co-transferred with wild-type T cells into wild-type hosts are found in lower proportions in lymph nodes indicating a defect in lymph node entry (J:141431)
• mutant T cells have a 3-fold less ability to egress out of a wild-type lymph node over a 20 hour period (J:141431)
• T cells within a lymph node move at a lower median velocity of 6.6 microm/min compared to 9.5 micormeter/minute for wild-type (J:141431)
• T cells within a lymph node also have larger turning angles and less-directed paths than their wild-type counterparts (J:141431)
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12 (J:141431)
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21 (J:141431)
• mutant T cells co-transferred with wild-type T cells into wild-type hosts are found in lower proportions in lymph nodes indicating a defect in lymph node entry (J:141431)
• mutant T cells have a 3-fold less ability to egress out of a wild-type lymph node over a 20 hour period (J:141431)
• T cells within a lymph node move at a lower median velocity of 6.6 microm/min compared to 9.5 micormeter/minute for wild-type (J:141431)
• T cells within a lymph node also have larger turning angles and less-directed paths than their wild-type counterparts (J:141431)
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls (J:141431)
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included (J:141431)
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls (J:141431)
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included (J:141431)

hematopoietic system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls (J:141431)
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls (J:141431)
• CD4+ T cell numbers in the periphery are decreased around 10-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD4+ T cell numbers in the periphery are decreased around 10-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD8+ T cell numbers in the periphery are decreased around 5-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• CD8+ T cell numbers in the periphery are decreased around 5-fold (J:141431)
• even more dramatic reductions are observed in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12 (J:141431)
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21 (J:141431)
• mutant T cells co-transferred with wild-type T cells into wild-type hosts are found in lower proportions in lymph nodes indicating a defect in lymph node entry (J:141431)
• mutant T cells have a 3-fold less ability to egress out of a wild-type lymph node over a 20 hour period (J:141431)
• T cells within a lymph node move at a lower median velocity of 6.6 microm/min compared to 9.5 micormeter/minute for wild-type (J:141431)
• T cells within a lymph node also have larger turning angles and less-directed paths than their wild-type counterparts (J:141431)
• in vitro transwell assays demonstrate migration defects in thymic CD4+ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12 (J:141431)
• similar defects are observed in the migratory response of CD4+CD8+ T cells to CXCL12 and of splenic CD4+ T cells to CCL21 (J:141431)
• mutant T cells co-transferred with wild-type T cells into wild-type hosts are found in lower proportions in lymph nodes indicating a defect in lymph node entry (J:141431)
• mutant T cells have a 3-fold less ability to egress out of a wild-type lymph node over a 20 hour period (J:141431)
• T cells within a lymph node move at a lower median velocity of 6.6 microm/min compared to 9.5 micormeter/minute for wild-type (J:141431)
• T cells within a lymph node also have larger turning angles and less-directed paths than their wild-type counterparts (J:141431)
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls (J:141431)
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included (J:141431)
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls (J:141431)
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included (J:141431)

cellular
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)
• na´ve CD4+ T cells have about 3-fold higher rates of apoptosis in the spleen (J:141431)

endocrine/exocrine glands
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is about doubled in these mice (J:141431)
• similar accumulations of mature T cells in the thymus occurs in irradiated wild-type mice reconstituted with mutant bone marrow (J:141431)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory