Phenotypes Associated with This Genotype

Genotype
MGI:3818516

• Allelic Composition: Nr6a1^tm2Coo/Nr6a1^tm2Coo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:80978 )

• normal ratio of homozygotes at E8.5-9.5

• no homozygotes after E10.5

embryo

abnormal developmental patterning ( J:80978 )

failure of initiation of embryo turning ( J:80978 )

• embryos normal to E8

• do not undergo turning

incomplete rostral neuropore closure ( J:80978 )

• anterior neural tube fails to close although it continues to grow

abnormal primitive streak morphology ( J:80978 )

• large invagination of neural epithelium within the primitive streak at E8.5

incomplete somite formation ( J:80978 )

• no more than 13 somites form

• reduced trunk and posterior structures

abnormal tail bud morphology ( J:80978 )

• tail bud protrudes from the yolk sac at E9.5

abnormal extraembryonic tissue morphology ( J:80978 )

abnormal allantois morphology ( J:80978 )

• protrusion of tissue at the base of the allantois starting at E8.75

• often fails to attach to the chorion

enlarged allantois ( J:80978 )

• often

abnormal chorion morphology ( J:80978 )

• often unattached to allantois

failure of chorioallantoic fusion ( J:80978 )

• allantois often fails to attach to the chorion

nervous system

incomplete rostral neuropore closure ( J:80978 )

• anterior neural tube fails to close although it continues to grow

digestive/alimentary system

absent hindgut ( J:80978 )

• hindgut fails to form

cardiovascular system

distended pericardium ( J:80978 )

• pericardium is often dilated

limbs/digits/tail

abnormal tail bud morphology ( J:80978 )

• tail bud protrudes from the yolk sac at E9.5