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Phenotypes Associated with This Genotype
Genotype
MGI:3818485
Allelic
Composition		 Ptprcaptm1Tkda/Ptprcaptm1Tkda
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprcaptm1Tkda mutation (1 available); any Ptprcap mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:48387 )
N
• normal leukocyte differentiation
decreased B cell proliferation ( J:48387 )
• reduced proliferative response of B cells to anti-IgM antibodies
decreased T cell proliferation ( J:48387 )
• significantly reduced proliferative response of T cells to TCR mediated stimuli
abnormal cytotoxic T cell physiology ( J:48387 )
• 50% reduction of cytotoxic leukocyte activity

hematopoietic system
decreased B cell proliferation ( J:48387 )
• reduced proliferative response of B cells to anti-IgM antibodies
decreased T cell proliferation ( J:48387 )
• significantly reduced proliferative response of T cells to TCR mediated stimuli
abnormal cytotoxic T cell physiology ( J:48387 )
• 50% reduction of cytotoxic leukocyte activity

cellular
decreased B cell proliferation ( J:48387 )
• reduced proliferative response of B cells to anti-IgM antibodies
decreased T cell proliferation ( J:48387 )
• significantly reduced proliferative response of T cells to TCR mediated stimuli

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory