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Phenotypes Associated with This Genotype
Genotype
MGI:3817583
Allelic
Composition
Zbtb7btm1Itan/Zbtb7btm2Itan
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1Itan mutation (0 available); any Zbtb7b mutation (24 available)
Zbtb7btm2Itan mutation (0 available); any Zbtb7b mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• an unusual double negative T cell population is found in the lymph nodes of these mice
• these double negative T cells all express GFP
• peripheral CD4+ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
• some CD8+ T cells express GFP

immune system
• an unusual double negative T cell population is found in the lymph nodes of these mice
• these double negative T cells all express GFP
• peripheral CD4+ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
• some CD8+ T cells express GFP


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory