Mouse Genome Informatics
ot
    Mecp2tm1Bird/Y
(129S6.129P2-Mecp2tm1Bird x FVB/N)F1
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no early mortality is observed in contrast to Mecp2-null animals

behavior/neurological
N
• Background Sensitivity: no overt abnormalities are observed; mutants do not exhibit impaired coordination in a variety of tests measured
• mice do not show overt abnormalities like tremor or limb grasping
• mice show decrease anxiety-related behavior in open field assays than wild-type mice
• percentage of time spent freezing is elevated relative to wild-type when placed back into the conditioning chamber
• percentage of time spent freezing is elevated relative to wild-type when re-exposure to a previously experienced cue
• increased number of vertical explorations is observed compared to wild-type; this is indicative of reduced anxiety
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity
• mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system
• mice show decreased prepulse inhibition compared to wild-type

respiratory system
• at 4 months, respiratory pattern is qualitatively different than in wild-type; coefficient of variability of the respiratory rhythm is higher than in wild-type
• increase in apnea incidence (39.5/hour) is observed compared to wild-type (5.8/hour)

growth/size/body
N
• Background Sensitivity: no size difference is detected relative to wild-type, unlike mice on the C57BL/6 background

integument
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:135825