Mouse Genome Informatics
ot
    Mecp2tm1Bird/Y
(129S6.129P2-Mecp2tm1Bird x C57BL/6)F1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
N
• no early mortality is observed in contrast to Mecp2-null animals (J:135825)

growth/size
• Background Sensitivity: a mild increase (animals are about 1 gram heavier) is observed relative to wild-type or F1 mutants from an FVB/N cross (J:135825)

behavior/neurological
• mice have a decreased startle response relative to wild-type (J:135825)
• Background Sensitivity: mice display impaired performance in coordination tasks like the rotating rod, hanging wire, and dowel walking tests (J:135825)
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity (J:135825)
• mice show increased latency in the hot plate assay (J:135825)
• mice show deficits in nest-building relative to wild-type, with fewer animals building or completing nests than wild-type animals over the same time period (J:135825)
• mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage (J:135825)

nervous system
• mice show decreased prepulse inhibition at 74 and 82 decibels compared to wild-type (J:135825)

integument
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity (J:135825)
• mice show increased latency in the hot plate assay (J:135825)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:135825