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Phenotypes Associated with This Genotype
Genotype
MGI:3817461
Allelic
Composition
Mecp2tm1Bird/Y
Genetic
Background
(129S6.129P2-Mecp2tm1Bird x C57BL/6)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no early mortality is observed in contrast to Mecp2-null animals

growth/size/body
• Background Sensitivity: a mild increase (animals are about 1 gram heavier) is observed relative to wild-type or F1 mutants from an FVB/N cross

behavior/neurological
• mice have a decreased startle response relative to wild-type
• Background Sensitivity: mice display impaired performance in coordination tasks like the rotating rod, hanging wire, and dowel walking tests
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity
• mice show increased latency in the hot plate assay
• mice show deficits in nest-building relative to wild-type, with fewer animals building or completing nests than wild-type animals over the same time period
• mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system
• mice show decreased prepulse inhibition at 74 and 82 decibels compared to wild-type

integument
• mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity
• mice show increased latency in the hot plate assay

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:135825


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory