About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3817455
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (42 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit increased mortality at 7 months of age
• 25% of mice die before 1 month

hematopoietic system
• in mice with acute myeloid leukemia (AML)
• increased in the spleen and bone marrow
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the peripheral blood of mice with acute myeloid leukemia (AML) contains more than 20% atypical cells with morphology consistent with blasts and immature myeloid precursors unlike in wild-type mice
• the bone marrow of mice with acute myeloid leukemia (AML)
• the spleen of mice of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis
• hematopoietic stem cell populations are expanded in the bone marrow and spleen compared to in wild-type mice and Arid4atm1Alb homozygotes
• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

neoplasm
• 83% of mice develop acute myeloid leukemia between 7 and 15 months of age
• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

liver/biliary system
• in mice with acute myeloid leukemia (AML)

skeleton
• mice that exhibit acute myeloid leukemia (AML) also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the bone marrow of mice with AML increase in granulocytes, monocytes, T lymphoid cells, and erythroid cells and a decrease in B lymphoid cells compared to in wild-type mice
• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice and Arid4atm1Alb homozygotes

respiratory system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

cardiovascular system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung, kidney and lymph node blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

renal/urinary system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

growth/size/body
• at 7 weeks of age, mice weigh 30% less than wild-type mice
• in mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)

immune system
• in mice with acute myeloid leukemia (AML)
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis
• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:141004


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2022
MGI 6.21
The Jackson Laboratory