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Phenotypes Associated with This Genotype
Genotype
MGI:3817277
Allelic
Composition
Itgaltm1Bll/Itgaltm1Bll
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles

cellular
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression

hematopoietic system
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory