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Phenotypes Associated with This Genotype
Genotype
MGI:3817243
Allelic
Composition
Tlx2tm1Htno/Tlx2tm1Htno
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlx2tm1Htno mutation (0 available); any Tlx2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% die by 3-5 weeks of age, while the rest survive for more than a year (J:42356)
• 50% die by 3-5 weeks of age, while the rest survive for more than a year (J:42356)
• 50% of homozygotes become sick with distended abdomen and die by 3-5 weeks of age; the rest appear normal and survive for more than a year (J:42356)
• 50% of homozygotes become sick with distended abdomen and die by 3-5 weeks of age; the rest appear normal and survive for more than a year (J:42356)

digestive/alimentary system
• a narrow segment spans from the proximal colon to the distal rectum in all cases of megacolon (J:42356)
• a narrow segment spans from the proximal colon to the distal rectum in all cases of megacolon (J:42356)
• thickness of the smooth muscle layer of the narrow segment of the colon is decreased (J:42356)
• thickness of the smooth muscle layer of the narrow segment of the colon is decreased (J:42356)
• 50% of homozygotes exhibit megacolon (J:42356)
• 50% of homozygotes exhibit megacolon (J:42356)
• small intestine is dilated (J:42356)
• small intestine is dilated (J:42356)

nervous system
• hyperinnervation of enteric neurons in the narrow segment of the megacolon (J:42356)
• hyperinnervation of enteric neurons in the narrow segment of the megacolon (J:42356)
• 7 of 12 homozygotes with megacolon exhibit degeneration of the enteric ganglia in the narrow segment of the colon (J:42356)
• 7 of 12 homozygotes with megacolon exhibit degeneration of the enteric ganglia in the narrow segment of the colon (J:42356)
• hyperinnervation of enteric neurons in the in the narrow segment of the megacolon (J:42356)
• hyperinnervation of enteric neurons in the in the narrow segment of the megacolon (J:42356)

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuronal Intestinal Dysplasia, Type B 601223 J:42356


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory