Phenotypes Associated with This Genotype

Genotype
MGI:3817222

• Allelic Composition: Sox9^tm1.1Gsr/Sox9⁺
• Genetic Background: involves: 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:141017 )

N • despite islet cell hypoplasia, pancreas size, weight and morphology are normal at E18.5

decreased PP cell number ( J:141017 )

• the number of polypeptide producing cells are reduced

decreased pancreatic alpha cell mass ( J:141017 )

• at E18.5, alpha cell mass is reduced 76% compared to in wild-type mice

decreased pancreatic beta cell mass ( J:141017 )

• at E18.5, beta cell mass is reduced 53% compared to in wild-type mice

decreased pancreatic delta cell number ( J:141017 )

• delta cell numbers are decreased compared to in wild-type mice

pancreatic islet hyperplasia ( J:141017 )

• mice exhibit islet hyperplasia

digestive/alimentary system

digestive/alimentary phenotype ( J:141017 )

N • despite islet cell hypoplasia, pancreas size, weight and morphology are normal at E18.5