Phenotypes Associated with This Genotype

Genotype
MGI:3815330

• Allelic Composition: Bag4^tm1Yeh/Bag4^tm1Yeh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:83559 )

• thymus cellularity is reduced by more than 25%

spleen hypoplasia ( J:83559 )

• mean spleen cellularity is reduced by about a third though variability exists between mice

abnormal macrophage physiology ( J:83559 )

• peritoneal resident macrophages produce significantly more nitrous oxide when incubated with IFN-gamma and TNF

increased circulating interleukin-6 level ( J:83559 )

• circulating IL-6 levels are significantly higher after injection of TNF

increased interleukin-6 secretion ( J:83559 )

• embryonic fibroblasts derived from these mice secrete a third more IL-6 when cultured with TNF

increased inflammatory response ( J:83559 )

• mice secrete more cytokines into circulation in response to injections of TNF

• circulating levels of IL-1 and IL-6 are greater than wild-type 2- and 4- hours after injection of TNF

• embryonic fibroblasts derived from these mice secrete a third more IL-6 when cultured with TNF

homeostasis/metabolism

increased circulating interleukin-6 level ( J:83559 )

• circulating IL-6 levels are significantly higher after injection of TNF

hematopoietic system

thymus hypoplasia ( J:83559 )

• thymus cellularity is reduced by more than 25%

spleen hypoplasia ( J:83559 )

• mean spleen cellularity is reduced by about a third though variability exists between mice

abnormal macrophage physiology ( J:83559 )

• peritoneal resident macrophages produce significantly more nitrous oxide when incubated with IFN-gamma and TNF

endocrine/exocrine glands

thymus hypoplasia ( J:83559 )

• thymus cellularity is reduced by more than 25%